At RENEW Med Spa Plus Wellness, we offer a convenient solution to start your child's Leucovorin wellness journey with our injectable Leucovorin combined with Vitamin B12 (methylcobalamin) and Magnesium sulfate. Our packages include everything you need for a seamless experience, from instructions to comprehensive guides on safely performing IM injections; all shipped directly to your home. With instructional videos, we make the process easy and accessible for you. 

The Leucovorin injections BOOST the folic acid getting to the brain and spinal cord with an almost 100% absorption rate vs. only 40% absorption with oral Leucovorin tablets.

​

• Additionally, folic acid requires B12 for absorption. Our injections include methylated B12 to ensure absorption into the brain and spinal cord.

• Oral Leucovorin does not contain any B12 to aid absorption

 

 

What is Leucovorin?

Leucovorin (also known as folinic acid) is an active, prescription-strength form of vitamin B9 that bypasses normal bodily conversion steps to quickly provide folate to cells.

 

​

What is Cerebral Folate Deficiency (CFD)?

Cerebral folate deficiency (CFD) is a neurological condition where the brain lacks sufficient folate (vitamin B9), even though blood folate levels can be entirely normal. This lack of brain folate leads to developmental delays, severe movement disorders, seizures, and progressive neurological decline.

 

​

Autism and Brain Health

In some patients with Cerebral Folate Deficiency (CFD), including certain individuals on the autism spectrum, leucovorin can help bypass a biological blockage that prevents standard folic acid from entering the brain. Some studies suggest it may help improve speech and language capabilities in a subset of these children – smaller studies suggest benefit; currently considered experimental though FDA-approval is pending.

 

​

Primary Symptoms

Symptoms typically present in infancy or early childhood (between 4 months and 2 years of age) and include: Cognitive issues and delay; Movement disorders – stimming, tip-toeing, poor eye contact, etc…; Delayed brain and spinal cord development.

 

​

Why Leucovorin Injections might be an option for your child (adult-child) with Autism.

Because standard oral folic acid supplements cannot bypass the transport barrier into the brain, it is typically treated using folinic acid (leucovorin). Folinic acid can effectively cross the blood-brain barrier to restore folate levels in the brain and help alleviate or stabilize symptoms.

 

​

Leucovorin (folinic acid) is currently being studied for its potential to improve specific symptoms in autistic children, primarily those with an underlying metabolic condition called Cerebral Folate Deficiency (CFD).

While not a universal treatment for autism, research and clinical observations suggest the following potential benefits for specific individuals on the autistic spectrum:

​

• Improved Verbal Communication: Small studies and clinical trials have shown that high-dose leucovorin can improve language skills and verbal communication, particularly in children with autism who also have language impairments.

• Enhanced Social Interaction: Some research indicates improvements in social engagement and responsiveness following treatment.

• Better Behavioral Regulation: Some families and researchers report reductions in irritability, repetitive behaviors, and emotional "shutdowns" or meltdowns.

• Increased Attention and Mood Stability: For some, the treatment may help with focus and emotional regulation, potentially by supporting the production of neurotransmitters like serotonin and dopamine.

 

 

​

The Biological Rationale (for Leucovorin use):

The rationale for using leucovorin centers on its ability to bypass certain blockages in the body's folate transport system:

​

• Bypassing Autoantibodies: Some autistic children have folate receptor autoantibodies (FRAA) that block folate from entering the brain. Leucovorin can use an alternative pathway to enter the central nervous system even when these receptors are blocked.

• Addressing Brain-Specific Deficiency: Individuals with CFD may have normal folate levels in their blood but dangerously low levels in their brain. Leucovorin helps restore these brain-specific levels, which are critical for healthy neurodevelopment.

 

​

​

Leucovorin studies are difficult to design as the disease is a SPECTRUM which means there is not just one form of the illness but rather different levels of autism. This is why many of the successful and positive studies showing benefits with Leucovorin are smaller studies; additionally, there is so much personal stories and posts online from parent’s of children with ASD explaining the benefits of using Leucovorin.

​

• In medicine, a spectrum refers to a continuous range of symptoms, severity, or conditions, rather than a rigid "yes/no" diagnosis. It is most widely used in psychiatry (for conditions like autism) and pharmacology (for medications like antibiotics) to describe varying degrees of an effect or diagnosis.

 

​

 

*** Spectrum Disorders***

​

Instead of a single disease, a spectrum disorder represents a wide continuum of related conditions or traits that share underlying features but vary greatly in severity.

 

Autism Spectrum Disorder (ASD): The most well-known example. It includes a broad range of developmental and communication challenges. An individual might be mildly impacted and highly independent, or severely impacted and require lifelong support.

 

Disclaimer: Leucovorin is a prescription medication and should only be used under the close supervision of a healthcare provider, as it can affect brain chemistry and requires careful monitoring for side effects.

 

RENEW Med Spa Plus Wellness offers injectable Leucovorin (10 weeks to start) combined with Vitamin B12 (methylcobalamin) and Magnesium sulfate (relaxation supplement) that is prepared and shipped directly to you to simplify the entire process. All supplies are included with dosing instructions, a guide on how to safely perform IM injections, as well as videos to provide further information to show how simple the injections truly are.

The Leucovorin injections BOOST the folic acid getting to the brain and spinal cord with an almost 100% absorption rate vs. only 40% absorption with oral Leucovorin tablets.

​

• Additionally, folic acid requires B12 for absorption. Our injections include methylated B12 to ensure absorption into the brain and spinal cord.

• Oral Leucovorin does not contain any B12 to aid absorption